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JTO:戒烟或可使肺癌患者活的更久

作者:佚名 2015-06-18 15:06:37 来源:医学论坛 阅读次数:4303


  近日,发表在国际杂志Journal of Thoracic Oncology上的一篇研究报道中,来自帕克癌症研究所(Roswell Park Cancer Institute)的研究人员通过研究表示,戒烟或可使肺癌病人活的更久一些;帕克癌症研究所拥有独特的烟草评估和戒烟服务(TACS),其可以针对肺癌患者开展标准化的烟草使用评估服务,并且为患者提供精细化的戒烟咨询服务。

  文章中,研究者对250名患者进行研究,这些个体中有50名最近开始戒烟,有71名个体在接触烟草评估和戒烟服务后才开始戒烟,结果表明,相比持续抽烟的个体而言,这些个体的死亡率明显降低了。进行戒烟服务的研究对象的生存中值达到了28个月,而持续吸烟的个体则为18个月。

  研究者Mary Reid说道,据我们所知,这项研究首次在在强制性评估和自动推荐烟草戒烟服务的条件下,检测了戒烟对于肺癌患者存活的影响。研究结果表明,尽管患者并没有完全停止烟草的使用,但戒烟对其还是有一定的生存益处的,在患者被诊断为肺癌后如果尝试去戒烟或可有效降低个体的死亡率。

  肺癌患者的烟草使用很少作为标准化的信息来收集,而一些前瞻性的方式也往往用于临床的研究中,本文研究中研究者所提供的TACS就可以标准化地收集患者的在诊断及后续治疗过程中的烟草使用信息,研究者指出,戒烟会明显改善肺癌患者的生存率,而标准的戒烟评估管理体系也应当用于临床实践中去。

  最后研究者Reid补充道,建立准确筛选烟草使用及戒烟程序等服务对于有效改善癌症患者的生活质量及生存率或将非常必要。

  doi:10.1097/JTO.0000000000000578

  PMC:

  PMID:

  Tobacco Cessation May Improve Lung Cancer Patient Survival.

  Dobson Amato KA1, Hyland A, Reed R, Mahoney MC, Marshall J, Giovino G, Bansal-Travers M, Ochs-Balcom HM, Zevon MA, Cummings KM, Nwogu C, Singh AK, Chen H, Warren GW, Reid M.

  INTRODUCTION: This study characterizes tobacco cessation patterns and the association of cessation with survival among lung cancer patients at Roswell Park Cancer Institute: an NCI Designated Comprehensive Cancer Center. METHODS: Lung cancer patients presenting at this institution were screened with a standardized tobacco assessment, and those who had used tobacco within the past 30 days were automatically referred to a telephone-based cessation service. Demographic, clinical information, and self-reported tobacco use at last contact were obtained via electronic medical records and the Roswell Park Cancer Institute tumor registry for all lung cancer patients referred to the service between October 2010 and October 2012. Descriptive statistics and Cox proportional hazards models were used to assess whether tobacco cessation and other factors were associated with lung cancer survival through May 2014. RESULTS: Calls were attempted to 313 of 388 lung cancer patients referred to the cessation service. Eighty percent of patients (250 of 313) were successfully contacted and participated in at least one telephone-based cessation call; 40.8% (102 of 250) of persons contacted reported having quit at the last contact. After controlling for age, pack year history, sex, Eastern Cooperative Oncology Group performance status, time between diagnosis and last contact, tumor histology, and clinical stage, a statistically significant increase in survival was associated with quitting compared with continued tobacco use at last contact (HR = 1.79; 95% confidence interval: 1.14-2.82) with a median 9 month improvement in overall survival. CONCLUSIONS: Tobacco cessation among lung cancer patients after diagnosis may increase overall survival.


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